The Longevity Machine: A journey to uncover the mysteries of aging

The Longevity Machine aims to answer a variety of questions about aging. What is this experiment about? What have you discovered so far? Please find the answer in the article below.

latest update: April 29, 2023

The Longevity Machine is the colloquial name for one of the most ambitious experiments of our time..This is a program called life machine, developed by scientists at the Center for Genomic Regulation in Barcelona. Their goal: to solve the mysteries of aging.

This is a topic that still has many unanswered questions. In fact, one researcher calls this process a “game of roulette” because, for example, two identical twins tend to be very different in age. life machine Aiming to decipher such riddles.

in principle, Age is calculated using date of birth as reference point. However, it is possible for one person to look much younger than another person of the same age, even if they live the same lifestyle. Why does it happen? This machine attempts to clarify that.

“There is still some debate whether a maximum lifespan exists. Experts can look at the same data and come to opposite conclusions. To be sure, in many countries we have seen an average increase in life expectancy of ten years over the last century. Why This Shouldn’t this situation continue?

– Nicholas Strustrup to Le Monde –

longevity machine

Adult couple having fun
The experiment aims to find answers to the mysteries of aging pathways.

The longevity machine research team is led by Nicholas Stroustrup, he conceived the project while a PhD student at Harvard University. His first experimental subjects were worms, examined in unstable equipment.

The preliminary results of his observations appeared in nature magazine2016, and noted that the dynamics of organismal aging in a constant genetic and environmental context provide a basis for assessing the processes that determine life duration.

Now, What have you done Center for Genomic Regulation will analyze the behavior of thousands of nematodes from birth to death. These samples are continuously monitored. The devices generate images of each animal every hour.

This continues for several months, eventually producing a large amount of data that will be the subject of subsequent statistical analysis. With these conclusions, the researchers hope to develop mathematical models to predict an organism’s life expectancy and future health.

It is estimated that there are more than 20,000 worms in the laboratory. They have 35 permanently activated scanners in cold storage rooms. At first glance, you can see the difference between young worms and old worms: the former do not stop moving, while the latter are more passive.

This supports one of Strausstrup’s hypotheses, derived from his first research as a student: Aging and mobility are closely related factors.

biological age

Elderly man exercising outdoors
great purpose life machine is to provide valuable data to predict life expectancy.

Humans continue to use chronological age as a parameter because as of yet there is no device to accurately measure biological age.. However, it has long been known intuitively that some people’s two ages do not coincide. For example, some people are 30 years old but look 45 or older. Everyone else is 50 and everyone thinks they are younger.

Regardless of age, as mentioned in an article Science and Culture Notebook, this number is inconsistent with the age of the organization. The argument is that certain structures that make up the body have only a minimal amount of time to exist, and only a few are present from birth.

thanks for this project life machine, Today we know that there is not just one biological age, but at least two.This is shown by the conclusions published in the journal PlosComputational Biology.

One age is determined by what scientists call “cessation of strenuous exercise.”. This means that changes in physical activity intensity are related to aging. Regardless of chronological age, the less strenuous the exercise, the more severe the aging process.

Another type of biological age is the age at which an organism dies. The two are positively correlated.

The longevity machine has a long way to go

Dr. Nicholas Stroustrup firmly believes that, in fact, a range of ages within the same organism. In humans, a person may be 60 years old, but the cells in their organs may be younger.

The difficulty in unraveling these mysteries is that it is not yet possible to conduct such experiments on humans. It may take centuries to produce results. Regardless, having a solid foundation to confirm this is a big step forward. In the same individual, multiple aging processes may occur simultaneously.

Longevity machines will provide valuable data to achieve what science has always pursued: extending life. Currently, they are studying how each gene changes over the years. Whether it is possible to halt aging and what the pathways to achieve this are are still far from known.

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